The Science Behind Vasonoxol
Discover Vasonoxol®'s nitric oxide system — a physician-formulated approach to cardiovascular wellness and healthy circulation.
The Mind Behind the Formula
Chief Science OfficerDr. Bernard J. Fragomeni
BCDNM, FAAMFM, ABAAHP, CPFM
Chief Science Officer / Head of Product Development
Dr. Bernard J. Fragomeni is the Chief Science Officer at Clinical & Herbal Innovations and the visionary behind the Vasonoxol formula. As the founder and CEO of the HumanBeing to Wellbeing Companies and the Functional Medicine Society of Utah, Dr. Fragomeni has dedicated his career to bridging the gap between clinical science and natural health solutions.
A board-certified doctor of naturopathic medicine and fellow of the American Academy of Anti-Aging and Metabolic Medicine, Dr. Fragomeni brings decades of expertise in functional medicine, cardiovascular wellness, and nutritional science. His mission is to provide the most effective, physician-formulated natural alternatives that help people take control of their health — without the damaging side effects of conventional medications.
Ingredients
L-arginine and L-citrulline, two essential amino acids that support the body's natural synthesis of nitric oxide (NO), are the building blocks of VASONOXOL.
L-ARGININE
An amino acid that fuels nitric oxide production, widening blood vessels and improving blood flow.
L-CITRULLINE
Works with L-Arginine to enhance nitric oxide levels and support vascular efficiency.
HORSE CHESTNUT SEED EXTRACT
Used to support circulation and vein integrity in smaller blood vessels.
GINKGO BILOBA EXTRACT
Supports blood flow to the brain, aiding focus and circulation.
RED YEAST RICE POWDER
Helps maintain healthy cholesterol and supports cardiovascular health.
CAYENNE PEPPER EXTRACT
Stimulates metabolism and circulation for cardiovascular support.
L-ARGININE
An amino acid that fuels nitric oxide production, widening blood vessels and improving blood flow.
Key Benefits
- Serves as the direct precursor for nitric oxide (NO) synthesis
- Promotes vasodilation by relaxing blood vessel walls
- Improves blood flow throughout the cardiovascular system
- Helps reduce elevated blood pressure naturally
- Supports endothelial function and vascular health
Clinical Evidence
- Studies show improved symptoms in stroke-like episodes (MELAS patients)
- Demonstrated enhancement of NO bioavailability when combined with L-Citrulline
- Helps reverse endothelial dysfunction
- Supports cardiovascular risk reduction
L-Arginine is converted by endothelial nitric oxide synthase (eNOS) into nitric oxide, a crucial signaling molecule that causes blood vessels to relax and widen. This vasodilation directly reduces pressure against artery walls and improves circulation throughout the body, including to the brain and vital organs.
L-CITRULLINE
Works with L-Arginine to enhance nitric oxide levels and support vascular efficiency.
Key Benefits
- Inhibits arginase enzyme, preserving L-Arginine for NO production
- More bioavailable than direct L-Arginine supplementation
- Enhances sustained nitric oxide synthesis
- Improves vascular markers and endothelial function
- Reduces blood pressure in hypertensive individuals
- Supports athletic performance and circulation
Clinical Evidence
- ICU patient studies showed improved metabolic markers (blood sugar, cholesterol, inflammation)
- Reduced duration of invasive ventilation in critical care
- Combination with L-Arginine reverses endothelial dysfunction
- Demonstrated vasodilation and improved exercise performance
L-Citrulline is converted in the kidneys to L-Arginine, bypassing "first-pass" metabolism in the liver and intestines. This makes it more efficient at increasing systemic L-Arginine levels. It also inhibits arginase, the enzyme that breaks down L-Arginine, ensuring more substrate is available for nitric oxide production. This dual action creates a sustained and powerful enhancement of NO synthesis.
HORSE CHESTNUT SEED EXTRACT
Used to support circulation and vein integrity in smaller blood vessels.
Key Benefits
- "Improves venous circulation via its active compound aescin (escin)
- Strengthens capillaries and prevents vascular leakage
- Reduces edema, leg pain, and swelling
- Anti-inflammatory properties protect blood vessel walls
- Supports overall circulatory integrity and vein health"
Clinical Evidence
- "Systematic reviews confirm efficacy for chronic venous insufficiency (CVI)
- Comparable to compression therapy for reducing CVI symptoms
- Shown to reduce ankle and calf circumference in clinical trials
- Aescin attenuated cognitive deficits in cerebral ischemia models"
The active compound aescin acts as a venotonic agent, improving the tone, strength, and health of veins. It seals leaking capillaries, improves the elastic strength of veins, and inhibits enzymes that damage blood vessel walls. This reduces swelling and inflammation while enhancing overall circulatory integrity.
GINKGO BILOBA EXTRACT
Supports blood flow to the brain, aiding focus and circulation.
Key Benefits
- "Enhances blood flow throughout the body, especially to the brain
- Potent antioxidant containing flavonoids and terpenoids
- Improves endothelial function and vascular health
- Exhibits ACE-inhibiting activity similar to BP medications
- Neuroprotective properties support cognitive function"
Clinical Evidence
- Meta-analysis of 27 RCTs showed improved outcomes in ischemic stroke patients
- Studies suggest benefit for dementia at doses above 200 mg/day
- Animal studies demonstrate blood pressure normalization via antioxidant mechanisms
- Shown to improve endothelial dysfunction in hypertensive models
Ginkgo Biloba acts as a potent antioxidant, protecting blood vessels from oxidative damage. It improves endothelial dysfunction and exhibits ACE-inhibiting activity — the same mechanism used by a major class of blood pressure medications. This provides a complementary pathway for blood pressure reduction alongside the primary NO-boosting ingredients.
RED YEAST RICE POWDER
Helps maintain healthy cholesterol and supports cardiovascular health.
Key Benefits
- "Supports healthy LDL and total cholesterol levels
- Contains monacolin K which inhibits cholesterol synthesis
- Reduces oxidative stress in blood vessels
- Prevents eNOS enzyme uncoupling for better NO production
- Makes endothelium less susceptible to cholesterol plaque formation"
Clinical Evidence
- "Demonstrated 15-25% reduction in LDL cholesterol across multiple studies
- Large clinical trial (1,445 patients) showed 44.1% reduced stroke risk
- Shown to improve vascular function by reducing oxidative stress
- Enhances efficiency of the NO-cGMP signaling pathway"
Red Yeast Rice contains monacolin K, which inhibits HMG-CoA reductase — a key enzyme in cholesterol production. Beyond cholesterol management, it reduces oxidative stress and prevents the uncoupling of eNOS, ensuring the enzyme produces beneficial nitric oxide instead of harmful superoxide radicals. This dual action synergizes with L-Arginine and L-Citrulline.
CAYENNE PEPPER EXTRACT
Stimulates metabolism and circulation for cardiovascular support.
Key Benefits
- "Contains capsaicin which activates TRPV1 receptors for vasodilation
- Potent antioxidant and anti-inflammatory properties
- Stimulates metabolism and improves circulation
- Rich in vitamin C and provitamin A
- Supports healthy blood flow and cardiovascular function"
Clinical Evidence
- "Experimental research demonstrates neuroprotective and vasoprotective properties
- Shown to inhibit platelet aggregation and blood coagulation in vitro
- May improve stroke risk factors including hypertension and atherosclerosis
- Capsaicin shown to release vasodilating neuropeptides like CGRP"
Capsaicin, the active compound in cayenne pepper, activates TRPV1 channels which triggers the release of vasodilating neuropeptides like CGRP. This helps widen blood vessels and improve circulation. Its antioxidant and anti-inflammatory actions also protect blood vessels from oxidative damage while its anti-thrombotic properties help maintain healthy blood flow.
U.S. Patent-Protected Nitric Oxide Technology
Vasonoxol is the only nitric oxide supplement protected by a U.S. patent for this specific formulation and use. This protection validates its unique ingredient synergy and ensures a level of innovation generic nitric oxide products cannot replicate.
Awarded US-Patent
