The Foundation of Vascular Wellness Support

Welcome to our in-depth clinical look at Vascular Wellness Support. Dr. Elizabeth Owings, MD, writes in her published LinkedIn article that the ingredients of Panoxol (now trademarked as Vasonoxol), when combined with appropriate blood pressure control, diet, and exercise, can be expected to help prevent and recover from stroke. When evaluating the absolute best methods for Vascular Wellness Support, understanding how these ingredients interact with your cardiovascular system at a cellular level is paramount.

The 6-in-1 US-Patented VASONOXOL ingredients act at multiple points in the progression of endothelial dysfunction (and atherosclerotic disease), providing unparalleled Vascular Wellness Support.

Understanding Endothelial Dysfunction and Vascular Wellness Support

To grasp the true biological value of Vascular Wellness Support, one must understand the endothelium—the delicate, thin membrane that lines the inside of the heart and blood vessels. When this lining is compromised by age or poor diet, it leads to endothelial dysfunction.

US-Trademarked Vasonoxol ™ (formerly Panoxol) is a doctor-formulated, US-patented combination of L-arginine, L-citrulline, horse chestnut seed extract, Ginkgo biloba, cayenne pepper, and red yeast rice. This powerful formulation provides a novel non-prescription supplement to support the body's natural repair mechanisms and provide vital, daily Vascular Wellness Support.

The 6 Botanical Pillars of Vascular Wellness Support

1. L-Arginine: The Nitric Oxide Engine L-arginine is an amino acid, which means it is found in protein, in dilute form. It is the direct precursor to nitric oxide and the only substrate required for its synthesis, making it a critical, non-negotiable component of Vascular Wellness Support. Supplementing the diet with purified L-arginine increases nitric oxide levels, thereby ameliorating endothelial dysfunction and promoting wide, healthy blood vessels.

2. L-Citrulline: Sustained Vascular Wellness Support L-Citrulline has been shown to both inhibit arginase (which would otherwise turn arginine into uric acid instead of nitric oxide) and to improve arginine stores better than arginine itself. The combination of citrulline and arginine has been shown to reverse endothelial dysfunction. In addition, research from clinical institutions like the National Institutes of Health has shown that the combination of citrulline and arginine dramatically enhances nitric oxide bioavailability, creating a long-lasting foundation for Vascular Wellness Support.

3. Horse Chestnut: Venous Integrity Horse chestnut is best known for improving ankle swelling and shrinking swollen leg veins. However, its role in comprehensive Vascular Wellness Support goes much deeper. It has been shown to protect the endothelium, and also has an important role in stroke prevention and recovery. Aescin, the active ingredient, has been shown to prevent damaging inflammation and to downregulate inflammatory genes and upregulate genes involved in healing in a mouse model of stroke.

4. Cayenne Pepper: The Circulation Catalyst Cayenne, a potent antioxidant, acts as a rapid circulation catalyst within our Vascular Wellness Support formula. It has been shown to improve not only stroke risk, but several contributory risk factors, such as hypertension, atherosclerosis, diabetes, and obesity. By promoting immediate nutrient delivery, it ensures the other botanical ingredients are absorbed rapidly and efficiently.

5. Red Yeast Rice: Cholesterol Management Red Yeast Rice improves the cholesterol profile by reducing oxidative stress and limiting the expression of cell adhesion molecules. This powerful biological action makes the endothelium less 'sticky' and therefore significantly less likely to form dangerous cholesterol plaque—a vital aspect of long-term Vascular Wellness Support.

6. Ginkgo Biloba: Neuroprotective Circulation Ginkgo biloba is widely recognized as a neuroprotective supplement that helps protect the brain from injury in cases of absent or diminished blood flow. It improves blood flow to the brain in patients who have experienced a hemorrhagic stroke, and has been extensively studied and found helpful in both ischemic and hemorrhagic strokes. In a recent randomized, double-blind, placebo-controlled study of ischemia stroke, Gingko biloba administration tripled the likelihood of a 4-month improvement to half the original NIHSS score. This incredible cognitive and circulatory synergy is the ultimate hallmark of Vascular Wellness Support.

The Importance of Proactive Cardiovascular Habits

Relying on supplements alone is not enough for optimal Vascular Wellness Support. Dr. Owings emphasizes that these ingredients are most effective when combined with proactive lifestyle changes. High blood pressure places immense mechanical stress on the delicate endothelium, leading to micro-tears that can eventually develop into atherosclerotic plaques.

To maximize your Vascular Wellness Support, consider adopting a heart-healthy diet that emphasizes leafy greens, whole grains, and lean proteins while drastically reducing sodium intake. Regular aerobic exercise acts as a natural catalyst for nitric oxide production, perfectly complementing the amino acids in Vasonoxol. Furthermore, managing chronic stress can lower cortisol levels, preventing stress-induced vasoconstriction.

Integrating Vascular Wellness Support Into Your Routine

Achieving lasting cardiovascular health requires a synergistic approach. When you combine healthy lifestyle modifications with the targeted, patented botanical ingredients in Vasonoxol, you create a powerful, multi-faceted approach to daily Vascular Wellness Support.

Take a proactive step in your health journey today. Shop our US Patented Formula online to experience the comprehensive benefits of physician-engineered circulation support!

References

ⁱ From the National Institute of Neurological Disorders and Stroke website (http://www.ninds.nih.gov/disorders/stroke/preventing_stroke.htm)

ⁱⁱ Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag. 2007 Dec; 3(6): 853–876. Hadi AR, Hadi and Jassim Al Suwaidi

ⁱⁱⁱ Mechanism of endothelial dysfunction in chronic kidney disease. Clin Chim Acta. 2010 Oct 9;411(19-20):1412-20. doi:10.1016/j.cca.2010.06.019. Epub 2010 Jun 22. Malyszko J

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^v Homocysteine and endothelial dysfunction: a link with cardiovascular disease. J Nutr. 2000 Feb;130(2S Suppl):369S-372S. McDowell IF, Lang D.

^vi Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):509-15. doi: 10.1161/ATVBAHA.113.300156. Messner B, Bernhard D

^vii Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension. 2012 Apr;59(4):818-24. Wray DW1, Nishiyama SK, Harris RA, Zhao J, McDaniel J, Fjeldstad AS, Witman MA, Ives SJ, Barrett-O'Keefe Z, Richardson RS.

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^ix Arterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet; Am J Clin Nutr. 2005 Oct; 82(4): 751–759. Qiang Shi, et al.

^x Endarterectomy is a surgical procedure in which the plaque is actually removed from the wall of the vessel, usually in the neck.

^xi Pathogenesis of Leukoaraiosis: A Review. Stroke 1997; 28:652-659. Leonardo Pantoni, MD; Julio H. García, MD

^xii Meta Gene. 2013 Oct 15;1:8-14. doi: 10.1016/j.mgene.2013.09.001. ECollection 2013. The effect of citrulline and arginine supplementation on lactic acidemia in MELAS syndrome. El-Hattab AW1, Emrick LT2, Williamson KC2, Craigen WJ2, Scaglia F2.

^xiii Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability. Biochemical and Biophysical Research Communications. Volume 454, Issue 1, 7, November 2014, Pages 53–57. Morita M, Hayashi T, Ochiai M, Maeda M, Tomoe

^xiv Endothelial function impairment in chronic venous insufficiency: effect of some cardiovascular protectant agents. Angiology. 2009 Dec-2010 Jan;60(6):763-71. Carrasco OF1, Ranero A, Hong E, Vidrio H.

^xv Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes. Neurochemistry 57(2):119-127. Sept 2010. International. Leiming Zhang, Fenghua Fu, Xiumei Zhang, Mei Zhu, Tian Wang, Huaying Fan

^xvi Antioxidant activity of capsinoids. J Agric Food Chem. 2002 Dec 4;50(25):7396-401. Rosa A, Deiana M, Casu V, Paccagnini S, Appendino G, Ballero M, Dessí MA

^xvii Capsaicin may have important potential for promoting vascular and metabolic health. Open Heart. 2015 Jun 17;2(1):e000262. McCarty MF1, DiNicolantonio JJ2, O'Keefe JH2.

^xviii Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation. 2014 Sep 26;11:167. doi: 10.1186/s12974-014-0167-6. Jiang M, Li J, Peng Q, Liu Y, Liu W, Luo C, Peng J, Li J, Yung KK, Mo Z.

^xix Effect of ginkgolide B on brain metabolism and tissue oxygenation in severe haemorrhagic stroke. Int J Clin Exp Med. 2015 Mar 15;8(3):3522-9. Chi CL, Shen DF, Wang PJ, Li HL, Zhang L

^xx Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature. Curr Top Med Chem. 2015;15(21):2222-32. Nabavi SM, Habtemariam S, Daglia M, Braidy N, Loizzo MR, Tundis R, Nabavi SF

^xxi The Effect of Ginkgo biloba on Functional Outcome of Patients with Acute Ischemic Stroke: A Double-blind, Placebo-controlled, Randomized Clinical Trial. November 2013; Volume 22, Issue 8, Pages e557–e563 Darioush Savadi Oskouei, MD, Reza Rikhtegar, MD, Mazyar Hashemilar, MD, Homayoun Sadeghi-Bazargani, MD, PhD, Mohsen Sharifi-Bonab, MD, Elyar Sadeghi-Hokmabadi, MD, Sina Zarrintan, MD, Ehsan Sharifipour, MD

*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement, especially if you have a medical condition or are taking medications.*